ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has been linked to a number of opportunistic bacterial and fungal infections. Aspergillus and Candida have been identified as the primary fungal pathogens for COVID-19 co-infection. Recently, several cases of mucormycosis in COVID-19 patients have been reported worldwide, particularly in India. Now, remember that mucormycosis can be of different types like rhino-ocular-cerebral (ROCM), pulmonary, gastrointestinal, etc., here we are dealing with a case of rhino-ocular cerebral mucormycosis which not only occurred once but twice post covid-19 infection. As we recover from the epidemic and the pandemic, it is essential to look back and understand what led to the insane surge of mucormycosis in post-covid-19 patients, especially in our country, India. Mucor is ubiquitous and present constantly around us, so no single factor but an array of elements is responsible predominantly being the incorrect use of corticosteroids in uncontrolled diabetics, which led to severe immunosuppression, injury to the beta cells of the pancreas by the SARS-COV-2 in newly diagnosed diabetics. In such cases, it is important to evaluate the patient thoroughly and orbital exenteration is done depending upon the doctor's judgment and MRI findings. Following is a case report of one such patient with recurrent post COVID mucormycosis predisposed by uncontrolled diabetes mellitus and managed by orbital exenteration.
ABSTRACT
COVID-19 is a new out-breaking human disease characterized by a severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2). A pandemic state was swiftly declared by the World Health Organization due its fast transmissibility and huge human mortality index. After a brief introduction to the COVID-19 disease such as the ways of virus transportation inside the human body, the aim of this revision is to focus on the SARS-CoV2 infected erythrocyte properties which are considered biomarkers of COVID-19 patients and highlight the erythrocyte as a transporter for therapeutic drugs deliver in infected patients.
ABSTRACT
After explaining the meaning of SARS-CoV2, the protection rules for the disease caused by this virus are described in order to eradicate the resulting pandemic. Methods to differentiate asymptomatic from symptomatic patients will be mentioned. Human lungs, heart, kidney, endothelium and erythrocyte have specific binding sites for the SARS-CoV2. The aim of this opinion was to highlight some new disposable technology to identify two cell properties. One of them is the vascular endothelial cell (EC) receptor binding to the SARS-CoV2 and the other is related with red blood cells (RBCs) as SARS-CoV2 carrier. © 2021 - IOS Press. All rights reserved.
ABSTRACT
The description of the analytical clinical and experimental data has been presented for patients with COVID-19 from different countries. The article presents detailed description of the rheological situation in patients with neuropathic and cardiological problems, as well as the “COVID toes”, during development of COVID-19 infection. The data was compared with results of rheological studies in analogical groups of patients without COVID-19. The disease “COVID toes” was compared with Raynaud’ phenomenon). The article describes the effects of various anticoagulants on blood rheology and prevention coagulopathies after describing Protocols. In vivo and in vitro experiments evaluating a range of rheological parameters under different anticoagulants’ influence, were analyzed, RBC aggregation, RBC deformability and plasma viscosity were examined with innovative measurement technologies and quantitative methods. The work presents a new scientific focus and research area, able to “transport” the newest experimental and analytical conclusions to the clinical practice – for successful management and treatment of COVID-19 Pandemic.